- MDL-28170
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- $30.00 / 1mg
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2026-04-13
- CAS:88191-84-8
- Min. Order:
- Purity: 95.06%
- Supply Ability: 10g
- CALPAIN INHIBITOR III
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- $7.00 / 1KG
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2020-02-19
- CAS: 88191-84-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | CALPAIN INHIBITOR III Basic information |
| Product Name: | CALPAIN INHIBITOR III | | Synonyms: | Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem;CS-1705;CALPAIN INHIBITOR III;CARBOBEZOXY-VALINYL-PHENYLALANINALZ-VAL-PHE-CHO;CARBOBENZOXY-VALINYL-PHENYLALANINAL;MDL 28170;Z-VAL-PHE-ALDEHYDE;Z-VAL-PHE-CHO | | CAS: | 88191-84-8 | | MF: | C22H26N2O4 | | MW: | 382.45 | | EINECS: | 618-124-4 | | Product Categories: | inhibitor | | Mol File: | 88191-84-8.mol |  |
| | CALPAIN INHIBITOR III Chemical Properties |
| Boiling point | 595.6±50.0 °C(Predicted) | | density | 1.153±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 26 mg/mL | | pka | 11.05±0.46(Predicted) | | form | White lyophilized solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChIKey | NGBKFLTYGSREKK-ANYOKISRSA-N | | SMILES | C(OCC1=CC=CC=C1)(=O)N[C@H](C(NC(C=O)CC1=CC=CC=C1)=O)C(C)C |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2924297099 | | Storage Class | 11 - Combustible Solids |
| | CALPAIN INHIBITOR III Usage And Synthesis |
| Description | MDL-28170 (88191-84-8) is a potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons.1It penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration, ameliorating brain damage in a gerbil model of global ischemia.2Displays neuroprotective effects in neurotrauma rodent models.3Calpain I Ki= 8 nM; Cathepsin B Ki= 24 nM in isolated enzyme assays. IC50= 0.3 μM in intact cell assay.4 | | Uses | MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects. | | Uses | Inhibits calpain proteolysis | | Definition | ChEBI: A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpai
I and II, and is also a gamma-secretase inhibitor. | | General Description | A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity. | | Biological Activity | Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo . | | Biochem/physiol Actions | Cell permeable: yes | | References | [1] P.S. CHARD. Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: Involvement of calcium-activated proteases[J]. Neuroscience, 1995, 65 4: Pages 1099-1108. DOI:10.1016/0306-4522(94)00548-j
[2] PING-AN LI . Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia[J]. Neuroscience Letters, 1998, 247 1: Pages 17-20. DOI:10.1016/s0304-3940(98)00266-3
[3] STEPHANIE N THOMPSON. A pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model.[J]. Journal of neurotrauma, 2010, 27 12: 2233-2243. DOI:10.1089/neu.2010.1474
[4] SANKAR CHATTERJEE. d-Amino Acid Containing, High-Affinity Inhibitors of Recombinant Human Calpain I†[J]. Journal of Medicinal Chemistry, 1998, 41 15: 2663-2666. DOI:10.1021/jm980035y |
| | CALPAIN INHIBITOR III Preparation Products And Raw materials |
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