- Bis-Tos-PEG4
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- $29.00 / 1g
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2026-01-04
- CAS:37860-51-8
- Min. Order:
- Purity: 99.06%
- Supply Ability: 10g
- Tos-PEG5-Tos
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- $0.00 / 500g
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2025-06-07
- CAS:37860-51-8
- Min. Order: 500g
- Purity: >98.00%
- Supply Ability: 500g
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| | Tetraethylene glycol di-p-tosylate Basic information |
| Product Name: | Tetraethylene glycol di-p-tosylate | | Synonyms: | BIS[2-(2-TOSYLOXYETHOXY)ETHYL] ETHER;BIS[2-[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHYL] ETHER;TETRAETHYLENE GLYCOL BIS(P-TOLUENESULFONATE);TETRAETHYLENE GLYCOL DI-P-TOSYLATE;TETRAETHYLENE GLYCOL DITOSYLATE;Tetraethylene glycol di(p-toluenesulfonate);DRAFT CHECKER, AIRFLOW DETECTION POWDER;1,11-Bis(tosyloxy)-3,6,9-trioxaundecane | | CAS: | 37860-51-8 | | MF: | C22H30O9S2 | | MW: | 502.6 | | EINECS: | | | Product Categories: | | | Mol File: | 37860-51-8.mol |  |
| | Tetraethylene glycol di-p-tosylate Chemical Properties |
| Melting point | 65-69 °C | | Boiling point | 635.0±55.0 °C(Predicted) | | density | 1.242 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.53(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | colorless to yellow | | BRN | 1610992 | | InChI | InChI=1S/C22H30O9S2/c1-19-3-7-21(8-4-19)32(23,24)30-17-15-28-13-11-27-12-14-29-16-18-31-33(25,26)22-9-5-20(2)6-10-22/h3-10H,11-18H2,1-2H3 | | InChIKey | SLAONPBUWDUSSO-UHFFFAOYSA-N | | SMILES | O(CCOCCOS(C1=CC=C(C)C=C1)(=O)=O)CCOCCOS(C1=CC=C(C)C=C1)(=O)=O | | EPA Substance Registry System | Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, bis(4-methylbenzenesulfonate) (37860-51-8) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2909498090 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Tetraethylene glycol di-p-tosylate Usage And Synthesis |
| Description | Tos-PEG5-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | | Uses |
Tetraethylene glycol di(p-toluenesulfonate), also known as Tetraethylene glycol di-p-tosylate, was used in the preparation of donor-spacer-acceptor podand system, dual channel fluorosensor for Li+, Mg2+ and Ca2+.
| | Synthesis | 20.0 g of tetraethylene glycol triacetonitrile and 10.2 g of triethylamine were added to a reaction flask, 300 mL of acetonitrile was added to dissolve the mixture, and the mixture was cooled to 0-5°C in an ice bath. 19.0 g of p-toluenesulfonyl chloride was dissolved in 100 mL of acetonitrile and slowly added dropwise to the reaction mixture, the dropwise addition time was controlled at 1 hour. After the dropwise addition was completed, the temperature of the reaction mixture was raised to 20-25 °C and the reaction was continued for 12 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The crude product was separated by column chromatography using gradient elution with hexane:ethyl acetate (v/v=4:1) and hexane:ethyl acetate (v/v=1.5:1). In the eluate of hexane:ethyl acetate (v/v=4:1), 12.9 g of oily product (tetraethylene glycol di-p-toluenesulfonate) was obtained in 35.9% yield. In the eluate of hexane:ethyl acetate (v/v=1.5:1), 5.4 g of oily product (tetraethyleneglycol mono-p-toluenesulfonate) was obtained in 10.4% yield. | | IC 50 | PEGs | | storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year;
| | References | [1] Organic Letters, 2002, vol. 4, # 14, p. 2329 - 2332
[2] Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 11, p. 2094 - 2100
[3] Zhurnal Organicheskoi Khimii, 1990, vol. 26, # 11, p. 2425 - 2433
[4] Patent: CN105541736, 2016, A. Location in patent: Paragraph 0044; 0052
[5] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 9, p. 1573 - 1584 |
| | Tetraethylene glycol di-p-tosylate Preparation Products And Raw materials |
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