- TOFISOPAM
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- $10.00 / 1KG
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2021-08-11
- CAS:22345-47-7
- Min. Order: 1g
- Purity: 99
- Supply Ability: 100kg/kg
- TOFISOPAM 22345-47-7
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- $1.00 / 1g
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2019-07-31
- CAS:22345-47-7
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 300 Ton/Tons per Month china raw material pharmaceutical Tofisopam
- TOFISOPAM
-
- $14.00 / 1KG
-
2019-07-06
- CAS:22345-47-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 50KG
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| | TOFISOPAM Basic information |
| Product Name: | TOFISOPAM | | Synonyms: | TOFISOPAM;7,8-DIMETHOXY-1-(3,4-DIMETHOXYPHENYL)-5-ETHYL-4-METHYL-5H-2,3-BENZODIAZEPINE;1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-benzo[d][1,2]diazepine;Tosopam;TOFISOPAM 22345-47-7;1-(3,4-Dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine;5H-2,3-Benzodiazepine, 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl- (8CI, 9CI);tofizopam | | CAS: | 22345-47-7 | | MF: | C22H26N2O4 | | MW: | 382.45 | | EINECS: | 244-922-3 | | Product Categories: | | | Mol File: | 22345-47-7.mol |  |
| | TOFISOPAM Chemical Properties |
| Melting point | 155-159°C | | Boiling point | 509.61°C (rough estimate) | | density | 1.2098 (rough estimate) | | refractive index | 1.6500 (estimate) | | solubility | DMSO: ~14 mg/mL | | pka | 7.29±0.40(Predicted) | | form | solid | | color | white | | λmax | 310nm(MeOH)(lit.) | | Merck | 14,9503 | | Stability: | Hygroscopic | | InChI | 1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3 | | InChIKey | RUJBDQSFYCKFAA-UHFFFAOYSA-N | | SMILES | CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13 |
| Hazard Codes | Xn,N | | Risk Statements | 22-50 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 2 | | RTECS | DE9540000 | | HS Code | 2933.99.8290 | | HazardClass | 6.1(b) | | PackingGroup | III | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1 |
| | TOFISOPAM Usage And Synthesis |
| Originator | Grandaxine,Ozothine,France,1975 | | Uses | Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant. | | Definition | ChEBI: Tofisopam is an organic molecular entity. | | Manufacturing Process | A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)-
benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11
mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the
reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of
5H-2,3-benzodiazepine derivative are separated from the residue as small,
white crystals. The melting point is 133°C to 136°C (after recrystallizing from
absolute ethanol, 136°C) | | Therapeutic Function | Tranquilizer | | Biological Activity | Studies have reported th at tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer.', 'Ligand for the GABAA receptor benzodiazepine modulatory site. |
| | TOFISOPAM Preparation Products And Raw materials |
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