洋槐黄素
| 中文名称 | 洋槐黄素 |
|---|---|
| 中文同义词 | 洋槐黄素;洋槐黄素标准品;洋槐黄素对照品;3,7-二羟基-2-(3,4,5-三羟基苯基)-4H-苯并吡喃-4-酮;洋槐黄;刺槐乙素;洋槐黄素,10 MM DMSO 溶液;洋槐黄素 Robinetin |
| 英文名称 | ROBINETIN |
| 英文同义词 | ROBINETIN;3,3’,4’,5’,7-pentahydroxy-flavon;3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;norkanugin;3,7,3',4',5'-PENTAHYDROXYFLAVONE;5-HYDROXYFISETIN;3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4-benzopyrone;3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl-4H-1-benzopyran-4-one) (Robinetin) |
| CAS号 | 490-31-3 |
| 分子式 | C15H10O7 |
| 分子量 | 302.24 |
| EINECS号 | 207-709-6 |
| 相关类别 | 植物提取物;黄酮;标准品 -中药标准品;标准品，对照品;对照品;Flavanols;Penta-substituted Flavones |
| Mol文件 | 490-31-3.mol |
| 结构式 |  |
洋槐黄素 性质
| 熔点 | 326-328°C |
|---|---|
| 沸点 | 363.28°C (rough estimate) |
| 密度 | 1.3616 (rough estimate) |
| 折射率 | 1.4790 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO（微溶）、甲醇（微溶，加热） |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.82±0.40(Predicted) |
| 颜色 | 黄色至深黄色 |
| InChI | 1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H |
| InChIKey | SOEDEYVDCDYMMH-UHFFFAOYSA-N |
| SMILES | [o]1c2c([c](c(c1c3cc(c(c(c3)O)O)O)O)=O)ccc(c2)O |
| LogP | 2.550 (est) |
Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮，具有显着的“两种颜色”固有荧光特性，具有抗真菌、抗病毒、抗菌、抗突变和抗氧化活性。Robinetin 还可以抑制脂质过氧化和蛋白质糖基化。
Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner.
Robinetin inhibits the DNA synthesis in
Proteus vulgaris
, and the RNA synthesis in S.
aureus
.
Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore.