|
|
| | 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Basic information |
| Product Name: | 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID | | Synonyms: | 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID;2-PHENYL-1,3-THIAZOLE-5-CARBOXYLICACID2-PHENYL-1,3-OXAZOLE-5-CARBOXYLICACID;2-phenyl-1,3-thiazole-5-carboxylic acid;2-Phenyl-5-carboxythiazole;2-phenyl-5-thiazolecarboxylic acid;5-Thiazolecarboxylic acid, 2-phenyl- | | CAS: | 10058-38-5 | | MF: | C10H7NO2S | | MW: | 205.23 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties |
| Melting point | 186 °C | | Boiling point | 420.5±37.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 2.78±0.10(Predicted) | | Appearance | White to off-white Solid |
| HazardClass | IRRITANT | | HS Code | 2934208090 |
| | 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-phenylthiazole-5-carboxylic acid from ethyl 2-phenylthiazole-5-carboxylate: to a solution of ethyl 2-phenylthiazole-5-carboxylate (3.2 g, 13.8 mmol) in methanol (50 mL) was added a sodium hydroxide solution (130 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and subsequently concentrated under reduced pressure to remove methanol. The aqueous phase was acidified to pH=3 with aqueous hydrochloric acid (1 M) and subsequently extracted with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography, eluting to give 2-phenylthiazole-5-carboxylic acid (2.3 g, 81.8% yield).MS m/z [ESI]: 206.0 [M+H]+. | | References | [1] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0121; 0126; 0127
[2] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 288
[3] Journal of the American Chemical Society, 1943, vol. 65, p. 2167
[4] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
[5] Journal of Chemical Research, 2011, vol. 35, # 5, p. 313 - 316 |
| | 2-PHENYL-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials |
|