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| | 2-Methoxy-5-methylphenylboronic acid Basic information |
| | 2-Methoxy-5-methylphenylboronic acid Chemical Properties |
| Melting point | 92-97 °C (lit.) | | Boiling point | 342.0±52.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in methanol. | | form | powder to crystal | | pka | 8.65±0.58(Predicted) | | color | White to Almost white | | InChI | 1S/C8H11BO3/c1-6-3-4-8(12-2)7(5-6)9(10)11/h3-5,10-11H,1-2H3 | | InChIKey | CSVKZOZMPSRLTC-UHFFFAOYSA-N | | SMILES | COc1ccc(C)cc1B(O)O | | CAS DataBase Reference | 127972-00-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39-60-37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29319090 | | Storage Class | 13 - Non Combustible Solids |
| | 2-Methoxy-5-methylphenylboronic acid Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Reactant for:
- Coupling reactions
- Preparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants
- Rh-catalyzed asymmetric arylation of aldehydes
- Stereoselective hydroarylation reactions
- Suzuki-Miyaura cross-coupling
| | Uses | suzuki reaction | | Synthesis | To a solution of 2-bromo-1-methoxy-4-methylbenzene (1.39 g, 15 mmol) in tetrahydrofuran (THF) was slowly added n-butyllithium (15 mmol) dropwise under nitrogen protection and -78 °C. The solution was stirred for 1 h. The solution was then mixed with tetramethyl borate (100 mL). After maintaining -78 °C and stirring for 1 h, the solution was transferred to a solution of THF (100 mL) containing trimethyl borate (15 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Subsequently, the reaction mixture was poured into 3N hydrochloric acid (125 mL) and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellowish white solid product 2-methoxy-5-methylphenylboronic acid (2.2 g, 89% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 7.6 (s, 1H), 7.38 (d, J = 2.3 Hz, 1H), 7.19 (dd, J = 8.4 Hz, 2.3 Hz, 1H), 6.87 (d, J = 8.4 Hz, 1H), 3.78 (s, 3H), 2.2 (s, 3H). | | References | [1] Patent: US2004/19190, 2004, A1. Location in patent: Page 24
[2] Patent: US5688808, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5688810, 1997, A
[5] Patent: US5693647, 1997, A |
| | 2-Methoxy-5-methylphenylboronic acid Preparation Products And Raw materials |
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