- Nogalamycin
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- $548.00 / 5mg
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2025-12-22
- CAS:1404-15-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | NOGALAMYCIN Basic information |
| | NOGALAMYCIN Chemical Properties |
| Melting point | 195-196° (dec) | | alpha | D25 +425° (c = 0.11 in CHCl3) | | Boiling point | 658.61°C (rough estimate) | | density | 1.2095 (rough estimate) | | refractive index | 1.7650 (estimate) | | storage temp. | 2-8°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble | | form | A solid | | pka | 7.45 (60% ethanol) | | color | Orange-red solid from MeOH | | biological source | Streptomyces nogalater | | InChIKey | KGTDRFCXGRULNK-UHFFFAOYSA-N | | SMILES | COC1C(C)OC(OC2CC(C)(O)C(C(=O)OC)c3cc4C(=O)c5c6OC7OC(C)(C(O)C(C7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)C(OC)C1(C)OC |
| Hazard Codes | T | | Risk Statements | 45-46-61-20/21/22 | | Safety Statements | 53-22-36/37/39-45 | | WGK Germany | 3 | | RTECS | RA4550000 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Oral
Carc. 1B
Repr. 1B | | Toxicity | LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian) |
| | NOGALAMYCIN Usage And Synthesis |
| Uses | Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation. | | Uses | Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis. | | Definition | ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol. | | Biochem/physiol Actions | Anthracyclic antitumor antibiotic. | | Safety Profile | Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx. | | in vivo | Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3]. | Animal Model: | Rats[1] | | Dosage: | 0-1000 mug/kg | | Administration: | IP | | Result: | Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg. |
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| | NOGALAMYCIN Preparation Products And Raw materials |
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