- 2,3,5,6-Tetrafluoroaniline
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- $35.00 / 1kg
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2025-09-25
- CAS:700-17-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 2,3,5,6-Tetrafluoroaniline Basic information | | Uses |
| Product Name: | 2,3,5,6-Tetrafluoroaniline | | Synonyms: | 2,3,5,6-TETRAFLUOROBENZENAMINE;2,3,5,6-TETRAFLUOROANILINE;1-Amino-2,3,5,6-tetrafluorobenzene;2,3,5,6-Tetrafluoraniline;Aniline, 2,3,5,6-tetrafluoro-;Benzenamine, 2,3,5,6-tetrafluoro-;Tetrafluoroaniline3;2,3,5,6-Tetrafluoroaniline 98% | | CAS: | 700-17-4 | | MF: | C6H3F4N | | MW: | 165.09 | | EINECS: | 211-840-4 | | Product Categories: | Amines;C2 to C6;Nitrogen Compounds | | Mol File: | 700-17-4.mol |  |
| | 2,3,5,6-Tetrafluoroaniline Chemical Properties |
| Melting point | 31-32 °C(lit.) | | Boiling point | 158 °C(lit.) | | density | 1,744 g/cm3 | | Fp | 145 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | perchloric acid: soluble | | pka | -0.22±0.10(Predicted) | | form | powder to lump to clear liquid | | color | White or Colorless to Light orange to Yellow | | BRN | 2211579 | | InChI | InChI=1S/C6H3F4N/c7-2-1-3(8)5(10)6(11)4(2)9/h1H,11H2 | | InChIKey | SPSWJTZNOXMMMV-UHFFFAOYSA-N | | SMILES | C1(N)=C(F)C(F)=CC(F)=C1F | | CAS DataBase Reference | 700-17-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2,3,5,6-Tetrafluoroaniline(700-17-4) |
| Hazard Codes | Xi,T,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36/37/39-36 | | RIDADR | 2941 | | WGK Germany | 3 | | Hazard Note | Toxic | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29214200 |
| | 2,3,5,6-Tetrafluoroaniline Usage And Synthesis |
| Uses | 2,3,5,6-Tetrafluoroaniline is a white solid and an important pharmaceutical and pesticide intermediate. It can be used as a raw material to synthesize a variety of drugs that are effective in treating inflammation and depression, and has good pharmaceutical effects. | | Chemical Properties | WHITE CRYSTALLINE MASS | | Synthesis | The general procedure for the synthesis of 2,3,5,6-tetrafluoroaniline from 4-amino-2,3,5,6-tetrafluorobenzonitrile was as follows: 867.6 grams of sulfuric acid with a mass fraction of 90% was added to the reactor, and the temperature was raised to 100°C. The reaction was carried out at a uniform rate. Under stirring, 482 g of 4-amino-2,3,5,6-tetrafluorobenzonitrile was added at a uniform rate, and the addition process was controlled to be completed within 2 hours. After the addition was completed, the reaction temperature was maintained at 100 °C to continue the reaction for 3 hours. Subsequently, 165 g of water was added to the reaction system, the sulfuric acid concentration was diluted to 80%, and the reaction temperature was raised to 120 °C and maintained at this temperature for 10 hours. After that, the reaction temperature was further increased to 130°C and the reaction was continued for 5 hours. Upon completion of the reaction, the reaction system was cooled to room temperature. Under the cooling condition, 300 g of water was added to the reaction system, and then 1715 g of 45% aqueous sodium hydroxide solution was slowly added dropwise for neutralization until the pH reached 9. After the neutralization was completed, the temperature was raised for distillation, and ultimately, 410 g of a white solid product 2,3,5,6-tetrafluoroaniline was obtained with a purity of 99.8% and a yield of 98%. | | References | [1] Patent: CN107915647, 2018, A. Location in patent: Paragraph 0024; 0026; 0027; 0029
[2] C. A., 1968, vol. 69, p. 35787
[3] , Gmelin Handbook: F: PerFHalOrg.7, 1, page 1 - 84, |
| | 2,3,5,6-Tetrafluoroaniline Preparation Products And Raw materials |
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