3-(1-Piperazinyl)-1,2-benzisothiazole

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Products Intro:	Product Name:3-(piperazin-1-yl)benzo[d]isothiazole CAS:87691-87-0 Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG

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Products Intro:	Product Name:3-(1-Piperazinyl)-1,2-benzisothiazole CAS:87691-87-0 Purity:99% Package:25KG;5KG;1KG

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Tel:	+undefined-21-51877795
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Products Intro:	Product Name:3-(1-Piperazinyl)-1,2-benzisothiazole CAS:87691-87-0 Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

3-(1-Piperazinyl)-1,2-benzisothiazole manufacturers

3-(1-Piperazinyl)-1,2-benzisothiazole Basic information

Product Name:	3-(1-Piperazinyl)-1,2-benzisothiazole
Synonyms:	Ziprasidone Impurity 6（Ziprasidone EP Impurity A）;lurasidone-1;3-Piperazinyl-1,2-benzisothiazole (PRB);ASINEX-REAG BAS 13031053;3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE;1,2-BENZISOTHIAZOLE-3-(1-PIPERAZINYL);1-(1,2-BENZISOTHIAZOL-3-YL)PIPERAZINE;1-(1,2-BENZISOTHIAZOL-3-YL)-PIPERAZINE (BASE)
CAS:	87691-87-0
MF:	C11H13N3S
MW:	219.31
EINECS:	618-048-1
Product Categories:	Sulphur Derivatives;API intermediates;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Starting Raw Materials & Intermediates;87691-87-0
Mol File:	87691-87-0.mol

3-(1-Piperazinyl)-1,2-benzisothiazole Chemical Properties

Melting point	89.0 to 93.0 °C
Boiling point	320.2±35.0 °C(Predicted)
density	1.256
storage temp.	2-8°C
solubility	soluble in Methanol
pka	8.52±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
BRN	4253627
InChI	InChI=1S/C11H13N3S/c1-2-4-10-9(3-1)11(13-15-10)14-7-5-12-6-8-14/h1-4,12H,5-8H2
InChIKey	KRDOFMHJLWKXIU-UHFFFAOYSA-N
SMILES	S1C2=C(C=CC=C2)C(N2CCNCC2)=N1
LogP	2.14
CAS DataBase Reference	87691-87-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,T
Risk Statements	25-36/38
Safety Statements	26-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
HazardClass	IRRITANT
HS Code	29349990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2

MSDS Information

3-(1-Piperazinyl)-1,2-benzisothiazole Usage And Synthesis

Chemical Properties	3-(1-Piperazinyl)-1,2-benzisothiazole is Yellow Solid
Uses	3-(1-Piperazinyl)-1,2-benzisothiazole is a reagent used to synthesize Ziprasidione
Definition	ChEBI: ID11614 is a N-arylpiperazine.
IC 50	5-HT_1A Receptor: 190 nM (IC₅₀); 5-HT₂ Receptor: 110 nM (IC₅₀)
References	[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 23, p. 6552 - 6563 [2] Patent: CN108440520, 2018, A. Location in patent: Paragraph 0054; 0056; 0062; 0063 [3] Journal of Medicinal Chemistry, 1986, vol. 29, # 3, p. 359 - 369 [4] Patent: WO2010/38948, 2010, A2. Location in patent: Page/Page column 54-55 [5] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 12, p. 2139 - 2151

3-(1-Piperazinyl)-1,2-benzisothiazole Preparation Products And Raw materials

Raw materials	Ethanol, 2,2'-(1,2-benzisothiazol-3-ylimino)bis--->Benzoyl chloride, 2-(chlorothio)- (9CI)-->3-Chloro-1,2-benzisothiazole-->1,2-Benzisothiazol-3(2H)-one-->2,2'-dithiodibenzoyl chloride-->2,2'-Dithiosalicylic acid-->Piperazine-->3-Piperazinyl-1,2-benzisothiazole hydrochloride-->2-Chlorobenzonitrile
Preparation Products	PEROSPIRONE

Tag:3-(1-Piperazinyl)-1,2-benzisothiazole(87691-87-0) Related Product Information

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Isothiazole 1,2-Benzisothiazol-3(2H)-one 2,2'-Dithiobis(benzothiazole) Probenazole 2-Mercaptobenzothiazole 2-Methyl-4-isothiazolin-3-one Benzothiazole Ziprasidone hydrochloride monohydrate Ziprasidone QT Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One) 3-Oxo Ziprasidone (Ziprasidone Impurity B) Ziprasidone Sulfoxide 5,5'-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6'-dichloro-3-hydroxy-3,3'-biindoline-2,2'-dione Ziprasidone Ring-opened IMpurity (IMpurity C) Ziprasidone Impurity 3 Isopropylidene ziprasidone 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE