[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-

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[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- manufacturers

  • SAR502250
  • SAR502250 pictures
  • $1970.00
  • 2026-07-27
  • CAS:503860-57-9
  • Purity:
  • Supply Ability: 10g
[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- Basic information
Product Name:[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-
Synonyms:[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-;(S)-2-(2-(4-fluorophenyl)morpholino)-1-methyl-[4,4'-bipyrimidin]-6(1H)-one;SAR502250;SAR-502250,SAR502250
CAS:503860-57-9
MF:C19H18FN5O2
MW:367.38
EINECS:
Product Categories:
Mol File:503860-57-9.mol
[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- Structure
[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- Chemical Properties
Boiling point 547.2±60.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (272.20 mM; Need ultrasonic)
pka2.90±0.19(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- Usage And Synthesis
UsesSAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2].
in vivo

SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mice expressing P301L tau[2].
SAR502250 (10-30 mg/kg; p.o. once daily for 7 weeks) improves the cognitive deficit in transgenic APP(SW)/Tau(VLW) mice after infusion of Aβ25-35[2].
SAR502250 (10-30mg/kg; a single p.o.) significantly increases the percentage of lever-presses in the inter-response time (IRT) bin (49-96s), with a significant augmentation of the percentage of reinforced responses[2].
SAR502250 (30mg/kg; i.p. once daily for 28 d) ameliorates chronic stress-induced degradation of the physical state of the mice coat[2].
SAR502250 (10-60 mg/kg; a single p.o.) decreases hyperactivity produced by psychostimulantsin mice[2].

Animal Model:Female P301L human tau transgenic mice (three-month-old; 32 g)[2]
Dosage:1, 3, 10, 30, 100 mg/kg
Administration:A single p.o.
Result:Attenuated dose-dependently tau phosphorylation in the cortex and spinal cord, with ED50s of 12.5 and 11.5mg/kg, respectively.
IC 50hGSK-3β: 12 nM (IC50)
References[1] Fukunaga K, et, al. 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7. DOI:10.1016/j.bmcl.2013.09.020
[2] Griebel G, et, al. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents. Sci Rep. 2019 Dec 2;9(1):18045. DOI:10.1038/s41598-019-54557-5
[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl- Preparation Products And Raw materials
Raw materials[4,4'-Bipyrimidin]-6(1H)-one,2-chloro-1-methyl--->Morpholine, 2-(4-fluorophenyl)-, (2S)-
Tag:[4,4'-Bipyrimidin]-6(1H)-one, 2-[(2S)-2-(4-fluorophenyl)-4-morpholinyl]-1-methyl-(503860-57-9) Related Product Information
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