4-Bromobenzo[b]thiophene

4-Bromobenzo[b]thiophene Suppliers list

Company Name:	PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Tel:	+8613572219112
Email:	info@pushanshiye.com
Products Intro:	Product Name:4-Bromobenzo[b]thiophene CAS:5118-13-8 Purity:98% Package:25kg

Company Name:	Capot Chemical Co.,Ltd.
Tel:	+86-（0）57185586718; +8613336195806
Email:	sales@capot.com
Products Intro:	Product Name:4-Bromobenzo[b]thiophene CAS:5118-13-8 Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg

Company Name:	Beijing Cooperate Pharmaceutical Co.,Ltd
Tel:	010-60279497
Email:	sales01@cooperate-pharm.com
Products Intro:	Product Name:4-BROMO-BENZO[B]THIOPHENE CAS:5118-13-8 Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG

Company Name:	Henan Tianfu Chemical Co.,Ltd.
Tel:	+86-0371-55170693 +86-19937530512
Email:	info@tianfuchem.com
Products Intro:	Product Name:CAS5118-13-8 4-BROMO-BENZO[B]THIOPHENE CAS:5118-13-8 Purity:99% Package:25KG;5KG;1KG

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	CAS:5118-13-8 Purity:0.99 Package:5G，10G，25G，50G，100G，250G,1KG

4-Bromobenzo[b]thiophene manufacturers

4-Bromobenzo[b]thiophene Basic information

Product Name:	4-Bromobenzo[b]thiophene
Synonyms:	4-BROMO-BENZO[B]THIOPHENE;4-Bromobenzothiophene;4-BROMO-1-BENZOTHIOPHENE;4-Bromothianaphthene;5-cyanobenzothiophene;4-bromo-thiophene;Benzo[b]thiophene,4-broMo-;4-Bromo-1-benzothiophene, 4-Bromothianaphthene
CAS:	5118-13-8
MF:	C8H5BrS
MW:	213.09
EINECS:	814-115-6
Product Categories:	Benzothiophene;Halogenated;Organohalides
Mol File:	5118-13-8.mol

4-Bromobenzo[b]thiophene Chemical Properties

Boiling point	144 °C(Press: 20 Torr)
density	1.649±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
form	solid
color	White to off-white
InChI	InChI=1S/C8H5BrS/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5H
InChIKey	QPBSEYFVZDMBFW-UHFFFAOYSA-N
SMILES	C12=CC=CC(Br)=C1C=CS2

Safety Information

MSDS Information

4-Bromobenzo[b]thiophene Usage And Synthesis

Synthesis	The traditional synthesis method is to take 2-bromo-6-fluorobenzaldehyde as a raw material, cyclize the raw material with mercaptoacetic acid in a DMF solvent to obtain 4-chlorobenzo [b] thiophene-2-carboxylic acid, and then decarboxylate the product at a high temperature in a quinoline/copper powder system to obtain the 4-chlorobenzo [b] thiophene.
Uses	4-Bromobenzo[b]thiophene is an important intermediate in the drug ipiprazole for the treatment of schizophrenia.
References	[1] Patent: US2017/158680, 2017, A1. Location in patent: Paragraph 0361; 0368; 0369 [2] Tetrahedron Letters, 2004, vol. 45, # 52, p. 9645 - 9647 [3] Organic Process Research and Development, 2012, vol. 16, # 8, p. 1449 - 1454 [4] Patent: WO2007/92751, 2007, A2. Location in patent: Page/Page column 20-21 [5] Patent: EP1724277, 2006, A1. Location in patent: Page/Page column 28-29

4-Bromobenzo[b]thiophene Preparation Products And Raw materials

Raw materials	4-BROMO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID-->Dimethyl sulfoxide-->Acetic acid-->Silver carbonate
Preparation Products	6-BROMO-BENZO[B]THIOPHENE-->(1-Benzothiophen-4-yl)boronic acid

Tag:4-Bromobenzo[b]thiophene(5118-13-8) Related Product Information

4-BROMO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Thianaphthene Brexpiprazole-d8 4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butan-1-ol 4-BROMO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Brexpiprazole Impurity 20 Brexpiprazole Impurity 36 Brexpiprazole Impurity 5 HCl Brexpiprazole Impurity 2 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one Brexpiprazole Impurity 7 Brexpiprazole Impurity 18 Brexpiprazole Impurity 24 Brexpiprazole Impurity 22 (E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE Brexpiprazole Impurity 21 8-(benzo[b]thiophen-4-yl)-5,8-diazaspiro[4.5]decan-5-ium chloride 5-HYDROXY-2(1H)-QUINOLINONE

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