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| | 5-BROMO-2-METHYL-PYRIMIDINE Basic information |
| | 5-BROMO-2-METHYL-PYRIMIDINE Chemical Properties |
| Melting point | 80.0 to 85.0 °C | | Boiling point | 195.2±13.0 °C(Predicted) | | density | 1.596±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | soluble in Methanol | | form | Solid | | pka | 0.46±0.22(Predicted) | | color | Light yellow to Brown | | λmax | 266nm(EtOH)(lit.) | | InChI | InChI=1S/C5H5BrN2/c1-4-7-2-5(6)3-8-4/h2-3H,1H3 | | InChIKey | NEDJTEXNSTUKHW-UHFFFAOYSA-N | | SMILES | C1(C)=NC=C(Br)C=N1 |
| Hazard Codes | Xi | | HS Code | 2933599590 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 5-BROMO-2-METHYL-PYRIMIDINE Usage And Synthesis |
| Uses | 5-BROMO-2-METHYL-PYRIMIDINE is a disubstituted pyrimidine derivative with strong insecticidal effects on house flies. | | Synthesis | General procedure for the synthesis of 5-bromo-2-methylpyrimidine from 2-methyl-5-bromopyrimidine-4-carboxylic acid: 5-bromo-2-methylpyrimidine-4-carboxylic acid (350 mg, 1.6 mmol) was dissolved in xylene (5 mL), and the reaction was carried out at reflux for 2 hours. After the reaction was completed, the reaction mixture was cooled to room temperature and directly sampled onto a silica gel column. Gradient elution with petroleum ether and petroleum ether solution containing 5% (v/v) ethyl acetate was carried out sequentially, and the target fraction was collected to give 5-bromo-2-methylpyrimidine (170 mg, 61% yield) as a white solid.LC-MS (m/z): 173 [M + H]+. 1H NMR (400 MHz, DMSO-d6) δ: 2.59 (s, 3H), 8.87 ( s, 2H). | | References | [1] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 176
[2] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0366
[3] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0320
[4] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 56
[5] Collection of Czechoslovak Chemical Communications, 1949, vol. 14, p. 223,228 |
| | 5-BROMO-2-METHYL-PYRIMIDINE Preparation Products And Raw materials |
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