| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:Pomalidomide-PEG3-Amine HCl salt
CAS:2446474-09-3
Purity:94% Package:100mg/RMB 11340.90;250mg/RMB 18480.90;500mg/RMB 33600.90
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Pomalidomide-PEG3-Amine HCl salt manufacturers
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| | Pomalidomide-PEG3-Amine HCl salt Basic information |
| Product Name: | Pomalidomide-PEG3-Amine HCl salt | | Synonyms: | Pomalidomide-PEG3-Amine HCl salt;Pomalidomide-PEG3-Amine hydrochloride;Pomalidomide-NH-PEG3-amine hydrochloride;4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;Pomalidomide-PEG3-C2-NH2 hydrochloride;Thalidomide-NH-PEG3-NH2 HCl;Pomalidomide-PEG3-NH2.HCl;Thalidomide-NH-PEG3-C2-NH2 hydrochloride | | CAS: | 2446474-09-3 | | MF: | | | MW: | 484.93 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2446474-09-3.mol |  |
| | Pomalidomide-PEG3-Amine HCl salt Chemical Properties |
| storage temp. | 2-8°C | | form | Solid | | color | Light yellow to yellow | | InChI | 1S/C21H28N4O7/c22-6-8-30-10-12-32-13-11-31-9-7-23-15-3-1-2-14-18(15)21(29)25(20(14)28)16-4-5-17(26)24-19(16)27/h1-3,16,23H,4-13,22H2,(H,24,26,27) | | InChIKey | ALLUGXFCRRSPMS-UHFFFAOYSA-N | | SMILES | O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCN)=CC=C3)=O)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Pomalidomide-PEG3-Amine HCl salt Usage And Synthesis |
| Uses | Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | | Biological Activity | Pomalidomide 4'-PEG3-amine is a functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand. | | IC 50 | Cereblon | | storage | Desiccate at RT | | References | [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | Pomalidomide-PEG3-Amine HCl salt Preparation Products And Raw materials |
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