Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-

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Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Basic information
Product Name:Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-
Synonyms:Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-;ABM-14;4-[3-[4-(4-hydroxyphenyl)phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS:1973408-76-2
MF:C25H18F3N3O2S
MW:481.49
EINECS:
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Mol File:1973408-76-2.mol
Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Structure
Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Chemical Properties
Boiling point 620.0±65.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
form Solid
pka9.60±0.26(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Usage And Synthesis
UsesABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR[1].
Biological ActivityABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 to degrade AR[1].
References[1]. Meizhong Jin, et al. Compounds and methods for the targeted degradation of the androgen receptor. WO2016118666A1.
Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)- Preparation Products And Raw materials
Tag:Benzonitrile, 4-[3-(4'-hydroxy[1,1'-biphenyl]-4-yl)-4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl]-2-(trifluoromethyl)-(1973408-76-2) Related Product Information
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