1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-

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1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)- manufacturers

  • BAY-298
  • BAY-298 pictures
  • $3018.00
  • 2026-04-22
  • CAS:2471978-97-7
  • Purity:
  • Supply Ability: 10g
  • BAY-298
  • BAY-298 pictures
  • $3018.00
  • 2025-10-28
  • CAS:2471978-97-7
  • Purity:
  • Supply Ability: 10g
1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)- Basic information
Product Name:1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-
Synonyms:1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-;BAY-298;PF-06873600 (free base)
CAS:2471978-97-7
MF:C27H21ClFN3O2
MW:473.93
EINECS:
Product Categories:
Mol File:2471978-97-7.mol
1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)- Structure
1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)- Chemical Properties
Boiling point 653.6±55.0 °C(Predicted)
density 1.353±0.06 g/cm3(Predicted)
pka12.36±0.70(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)- Usage And Synthesis
UsesBAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels[1].
in vivo

BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus[1].
BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po[1].

Animal Model:Intact female rats[1]
Dosage:4.5, 9, 18, 36, 72 mg/kg
Administration:Oral; for 8 days
Result:Dosedependently lowered serum estradiol levels in proestrus.
Animal Model:Female and male Wistar rats[1]
Dosage:0.5 mg/kg of iv or 2 mg/kg of po
Administration:Iv or po
Result:Has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po.
References[1] Wortmann L, et al. Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels In Vivo. J Med Chem. 2019 Oct 31. DOI:10.1021/acs.jmedchem.9b01382
1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)- Preparation Products And Raw materials
Tag:1,6-Naphthyridine-6(5H)-carboxamide, 5-(4-chlorophenyl)-N-[4-(4-fluorophenoxy)phenyl]-7,8-dihydro-, (5S)-(2471978-97-7) Related Product Information
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