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Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- manufacturers
- NF-κΒ activator 2
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- $95.00
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2026-05-11
- CAS:2375281-44-8
- Purity: 99.32%
- Supply Ability: 10g
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| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- Basic information |
| Product Name: | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- | | Synonyms: | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]-;NF-κΒ activator 2;3-(2-((2-Fluorophenyl)amino)oxazol-5-yl)benzoic acid;Nuclear factor-kappaB,NF-κΒ activator 2,NF-κB,ALS,amyotrophic,Nuclear factor-κB,lateral,NF κΒ activator 2,NFκΒ activator 2,NF-?B,Inhibitor,SOD2,sclerosis,inhibit;3-{2-[(2-fluorophenyl)amino]-1,3-oxazol-5-yl}benzoic acid;NF-κΒ activator 2, 10 mM in DMSO;3-[2-(2-fluoroanilino)-1,3-oxazol-5-yl]benzoic acid | | CAS: | 2375281-44-8 | | MF: | C16H11FN2O3 | | MW: | 298.27 | | EINECS: | | | Product Categories: | | | Mol File: | 2375281-44-8.mol | ![Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- Structure](CAS/20200611/GIF/2375281-44-8.gif) |
| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- Chemical Properties |
| Boiling point | 512.1±60.0 °C(Predicted) | | density | 1.396±0.06 g/cm3(Predicted) | | pka | 3.89±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- Usage And Synthesis |
| Uses | NF-κΒ activator 2 is a potent and orally active NF-B activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-B expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. | | in vivo | NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice[1].
NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and Cmax (92 ng/mL)[1]. | | IC 50 | NF-κB: 1.58 μM (EC50) | | References | [1] Mathew B, et, al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-B activators for the treatment of ALS. Eur J Med Chem. 2020 Oct 22;112952. DOI:10.1016/j.ejmech.2020.112952 |
| | Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-5-oxazolyl]- Preparation Products And Raw materials |
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