3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- manufacturers
- MptpB-IN-1
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- $1980.00
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2026-05-11
- CAS:2244622-44-2
- Purity:
- Supply Ability: 10g
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| | 3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- Basic information |
| | 3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- Chemical Properties |
| Boiling point | 511.5±50.0 °C(Predicted) | | density | 1.473±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 3.09±0.36(Predicted) |
| | 3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- Usage And Synthesis |
| Uses | MptpB-IN-1 (Compound 13) is a potent and orally active inhibitor of MptpB. Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. MptpB-IN-1 reduces multidrug-resistant mycobacterium tuberculosis survival and infection burden[1]. | | References | [1] Vickers CF, et al. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo. J Med Chem. 2018;61(18):8337-8352. DOI:10.1021/acs.jmedchem.8b00832 |
| | 3-Isoxazolecarboxylic acid, 4-(3',5'-dichloro-4'-hydroxy[1,1'-biphenyl]-3-yl)-5-methyl- Preparation Products And Raw materials |
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