2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-

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2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Suppliers list
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Email: klq@cw-bio.com
Company Name: TargetMol Chemicals Inc.  
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2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- manufacturers

  • PNU-292137
  • PNU-292137 pictures
  • $2500.00
  • 2026-05-11
  • CAS:326823-27-2
  • Purity:
  • Supply Ability: 10g
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Basic information
Product Name:2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-
Synonyms:2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-;PNU 292137;PNU292137;PNU-292137
CAS:326823-27-2
MF:C18H17N3O
MW:291.35
EINECS:
Product Categories:
Mol File:326823-27-2.mol
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Structure
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Chemical Properties
Boiling point 621.7±50.0 °C(Predicted)
density 1.343±0.06 g/cm3(Predicted)
pka13.44±0.10(Predicted)
Safety Information
MSDS Information
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Usage And Synthesis
UsesPNU-292137 is an orally active, potent CDK2 inhibitor with IC50s of 37 nM and 92 nM for CDK2/cyclin A and CDK2/cyclin E, respectively. PNU-292137 makes interactions with the hydrophobic pocket at the back of the CDK2 ATP pocket. PNU-292137 efficiently inhibits tumor cell proliferation in human colon and prostate tumor cell lines. PNU-292137 exhibits antitumor activity (TGI>50%) in a mouse xenograft model[1].
IC 50CDK2/cyclinA: 37 nM (IC50); CDK2/cyclin E: 92 nM (IC50); Cdk5/p25: 114 nM (IC50); CDK1/cyclinB: 270 nM (IC50); CDK4/cyclinD1: >10000 nM (IC50); GSK-3β: 1905 nM (IC50); ERK-2: 4600 nM (IC50)
References[1] Paolo Pevarello, et al. 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding. J Med Chem. 2004 Jun 17;47(13):3367-80. DOI:10.1021/jm031145u
2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)- Preparation Products And Raw materials
Tag:2-Naphthaleneacetamide, N-(5-cyclopropyl-1H-pyrazol-3-yl)-(326823-27-2) Related Product Information
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