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INTATRADE GmbH |
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+49 3493/605464 |
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sales@intatrade.de |
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| | 3-Amino-3-methyl-butan-1-ol Basic information | | Uses |
| | 3-Amino-3-methyl-butan-1-ol Chemical Properties |
| Boiling point | 71 °C(Press: 9 Torr) | | density | 0.8380 g/cm3 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 15.42±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid |
| RIDADR | 2735 | | HazardClass | 8 | | PackingGroup | Ⅲ |
| | 3-Amino-3-methyl-butan-1-ol Usage And Synthesis |
| Uses | 3-Amino-3-methylbut-1-ol can be used as a pharmaceutical synthesis intermediate. | | Synthesis | Step 3 Synthesis of 3-amino-3-methyl-1-butanol: 3-benzylamino-3-methyl-1-butanol (3.86 g, 20.0 mmol) was dissolved in ethanol (80 mL) and 10% palladium carbon catalyst (400 mg) was added. The reaction mixture was stirred for 6 hours at room temperature under hydrogen atmosphere (5 kgf/cm2). Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was purified by distillation to afford the colorless oily product 3-amino-3-methyl-1-butanol (2.00 g, 97% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ1.21 (6H, s), 1.59 (2H, t, J=5.5 Hz), 2.63-2.76 (3H, br), 3.85 (2H, t, J=5.5 Hz). | | References | [1] Patent: US2007/254866, 2007, A1. Location in patent: Page/Page column 102 |
| | 3-Amino-3-methyl-butan-1-ol Preparation Products And Raw materials |
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