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| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Basic information |
| Product Name: | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | | Synonyms: | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP,;11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride;Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2);11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE;dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine;dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride;11-Piperazinodibenzo-[b,f][1,4]-thiazepin;N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl | | CAS: | 111974-74-4 | | MF: | C17H18ClN3S | | MW: | 331.86 | | EINECS: | 1312995-182-4 | | Product Categories: | Quetiapine;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;(intermediate of quetiapine fumarate) | | Mol File: | 111974-74-4.mol | ![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Structure](CAS/GIF/111974-74-4.gif) |
| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties |
| Melting point | 180-184°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in DMSO, Methanol, Distilled Water | | form | solid | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. | | Major Application | pharmaceutical | | InChI | InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H | | InChIKey | MJPARFLICDXWJT-UHFFFAOYSA-N | | SMILES | C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl | | CAS DataBase Reference | 111974-74-4(CAS DataBase Reference) |
| WGK Germany | WGK 3 | | HS Code | 2934990002 | | Storage Class | 11 - Combustible Solids |
| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Usage And Synthesis |
| Description | Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1 Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2 Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4 | | Chemical Properties | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid | | Uses | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic | | Uses | N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic. | | References | [1] A CARLO ALTAMURA. Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.[J]. Clinical Drug Investigation, 2012, 32 3: 213-219. DOI:10.2165/11597330-000000000-00000
[2] FRANCISCO LÓPEZ-MUÑOZ Cecilio A. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders.[J]. Frontiers in Psychiatry, 2013: 102. DOI:10.3389/fpsyt.2013.00102
[3] BARBARA DI BENEDETTO . N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant[J]. Neuropharmacology, 2012, 62 1: Pages 209-216. DOI:10.1016/j.neuropharm.2011.07.001
[4] CARL BJÖRKHOLM . Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine[J]. European Neuropsychopharmacology, 2013, 23 7: Pages 709-720. DOI:10.1016/j.euroneuro.2012.05.012 |
| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials |
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