- AMI-1
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- $40.00 / 25mg
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2026-04-13
- CAS:20324-87-2
- Min. Order:
- Purity: 99.98%
- Supply Ability: 10g
- AMI 1
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- $2.00 / 100kg
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2025-10-13
- CAS:20324-87-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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| | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Basic information |
| Product Name: | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) | | Synonyms: | 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate;AMI-1 - AMI-1 sodium salt;AMI-1;AMI 1;AMI1;disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate;disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate;disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate;J acid urea,disodiuM salt 70%;7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt | | CAS: | 20324-87-2 | | MF: | C21H17N2NaO9S2 | | MW: | 528.48 | | EINECS: | 243-735-4 | | Product Categories: | Inhibitors | | Mol File: | 20324-87-2.mol |  |
| | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Chemical Properties |
| | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Usage And Synthesis |
| Chemical Properties | Light grey paste. Soluble in water and easily soluble in alkaline solution. | | Uses | AMI-1 is a Histone Methyltransferase (HMT) inhibitor. | | Biological Activity | potent, cell permeable and specific protein arginine n-methyltransferase 1 (prmt1) inhibitor (ic50 = 8, 8 μm), does not compete for the adomet (s-adenosyl-l-methionine, sam) binding site, blocks peptide substrate binding, hiv-1 rt polymerase inhibitor (ic50 = 5, 0 μm). | | in vivo | AMI-1 (0.5 mg; intratumorally; daily; for 7 days) inhibits S180 viability in vivo[4].
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) downregulates PRMT5 but does not regulate the expression of PRMT7 in a tumor xenograft model[4].
AMI-1 (0.5 mg; intratumorally; daily; for 7 days) decreases the levels of H4R3me2s and H3R8me2s in a tumor xenograft model[4].
| Animal Model: | 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft[4] | | Dosage: | 0.5 mg | | Administration: | Intratumorally, daily, for 7 days | | Result: | Decreased tumor weight. |
| | IC 50 | PRMT1 |
| | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) Preparation Products And Raw materials |
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