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| | 1-Actamido-3,5-dimethyladmantane Basic information |
| | 1-Actamido-3,5-dimethyladmantane Chemical Properties |
| Melting point | 110-111°C | | Boiling point | 348.5±9.0 °C(Predicted) | | density | 1.05 | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly) | | pka | 16.20±0.60(Predicted) | | form | Solid | | color | White | | CAS DataBase Reference | 19982-07-1(CAS DataBase Reference) |
| WGK Germany | WGK 3 | | HS Code | 2902190000 | | Storage Class | 11 - Combustible Solids |
| | 1-Actamido-3,5-dimethyladmantane Usage And Synthesis |
| Chemical Properties | 1-Actamido-3,5-dimethyladmantane is White Solid | | Uses | 1-Actamido-3,5-dimethyladmantane is an intermediate used for preparation of Memantine (M218000). | | Synthesis | [0063] 1.00 g (5.50 mmol) of 3,5-dimethyl-1-adamantanol, 0.46 g (11.1 mmol) of acetonitrile, and 9.61 g of homotrimethylbenzene were added to a test tube with an outer diameter of 30 mm and mixed well. Subsequently, 1.12 g (11.1 mmol) of 97% concentrated sulfuric acid was slowly added dropwise to the mixed solution in the test tube to form a reaction solution. The reaction solution was stirred at a constant temperature at 30°C for 3 hours to promote the reaction. Upon completion of the reaction, 6.09 g of water was added to the reaction solution to quench the reaction, and the aqueous phase was removed by aqueous washing to obtain a homotrimethylbenzene solution containing 1-acetamido-3,5-dimethyladamantane (reaction yield: 80.4%). Next, 0.71 g of sodium hydroxide hydrate and 9.61 g of 1-hexanol were added to this solution to prepare a reaction solution. The reaction solution was stirred at 130 °C for 18 h to achieve hydrolysis of 1-acetamido-3,5-dimethyladamantane. Finally, the reaction solution was analyzed by gas chromatography (GC) to confirm the generation of memantine (reaction yield: 96.2%). | | References | [1] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 867 - 871
[2] Zhurnal Organicheskoi Khimii, 1982, vol. 18, # 5, p. 1001 - 1005
[3] Patent: EP2949643, 2015, A1. Location in patent: Paragraph 0063 |
| | 1-Actamido-3,5-dimethyladmantane Preparation Products And Raw materials |
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