TERTATOLOL
| 中文名称 | TERTATOLOL |
|---|---|
| 中文同义词 | 化合物 T17041;化合物 TERTATOLOL |
| 英文名称 | 1-(tert-butylamino)-3-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]propan-2-ol |
| 英文同义词 | 1-(tert-butylamino)-3-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]propan-2-ol;1-[[(3,4-Dihydro-2H-1-benzothiopyran)-8-yl]oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol;2-Propanol, 1-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-;Einecs 280-519-9;Racemic teraterol;Tertatolol [ban:inn];rac Tertatolol;RaceMic Tertatolol |
| CAS号 | 83688-84-0 |
| 分子式 | C16H25NO2S |
| 分子量 | 295.4402 |
| EINECS号 | 2805199 |
| 相关类别 | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds |
| Mol文件 | 83688-84-0.mol |
| 结构式 |  |
TERTATOLOL 性质
| 熔点 | 70-72 °C |
|---|---|
| 沸点 | 465.0±45.0 °C(Predicted) |
| 密度 | 1.112±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 13.84±0.20(Predicted) |
Tertatolol 是一种有效的 beta-adrenoceptor 和 5-HT receptor 拮抗剂，具有舒张血管的作用。
In serum-free media, tertatolol does not significantly alter the incorporation of 3 H-thymidine after 28 h of incubation in human mesangial cell (HMC). In the presence of 1% serum, tertatolol significantly reduces 3 H-thymidine incorporation. Tertatolol also inhibits 3 H incorporation when PDGF and thrombin are used as the stimulus. Tertatolol inhibits the reduction in planar surface area of HMC induced by angiotensin II. The inhibitory effect of tertatolol on HMC proliferation is also potentiated by ritanserin and MDL 72222, 5HT2 and 5HT3 antagonists, respectively.