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Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)-

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Products Intro: Product Name:NCGC00378430
CAS:920650-00-6
Purity:99.74% Package:1mg;68USD|5mg;163USD|10mg;245USD
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CAS:920650-00-6
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CAS:920650-00-6
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:NCGC00378430
CAS:920650-00-6
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Products Intro: Product Name:NCGC00378430
CAS:920650-00-6
Purity:99% Package:1mg;5mg;10mg

Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)- manufacturers

  • NCGC00378430
  • NCGC00378430 pictures
  • $68.00 / 1mg
  • 2024-11-18
  • CAS:920650-00-6
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  • Purity: 99.74%
  • Supply Ability: 10g
Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)- Basic information
Product Name:Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)-
Synonyms:Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)-;NCGC-00378430,Inhibitor,T47D,E-CAD,MCF7,Phosphatase,NCGC 00378430,TGF-β,inhibit,NCGC00378430,SIX1,p-Smad3,breast,EMT,cancer,FN1,transcriptional,EYA2;N-(4-Methoxy-3-(morpholinosulfonyl)phenyl)-3-(1H-pyrrol-1-yl)benzamide;NCGC00378430, 10 mM in DMSO;N-[4-Methoxy-3-(morpholine-4-sulfonyl)phenyl]-3-(1H-pyrrol-1-yl)benzamide
CAS:920650-00-6
MF:C22H23N3O5S
MW:441.5
EINECS:
Product Categories:
Mol File:920650-00-6.mol
Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)- Structure
Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)- Chemical Properties
density 1.34±0.1 g/cm3(Predicted)
form Solid
pka11.78±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)- Usage And Synthesis
UsesNCGC00378430 is a potent SIX1/EYA2 interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model[1].
in vivo

NCGC00378430 (25 mg/kg; local injection to the site of tumor; every other day; from day 3 until the day 21) dramatically decreases distant metastatic burden compared to vehicle treatment[1].
? NCGC00378430 (20 mg/kg; IV) has a T1/2α of 0.25 hours[1].

Animal Model:6-8 week old NSG mice with MCF7 tumor cells[1]
Dosage:25 mg/kg
Administration:Local Injection to the site of tumor; every other day; from day 3 until the day 21
Result:Dramatically decreased distant metastatic burden compared to vehicle treatment.
Had no growth inhibitory effect.
Animal Model:Mice[1]
Dosage:20 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a T1/2α of 0.25 hours, a CL of 6.19 L/hr?kg, a Vss of 4.08 L/kg, a Cmax of 6703 ng/mL and an AUC of 3234 ng/mL?hr.
References[1] Hengbo Zhou, et al. Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Res. 2020 Jun 15;80(12):2689-2702. DOI:10.1158/0008-5472.CAN-20-0435
Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)- Preparation Products And Raw materials
Tag:Benzamide, N-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]-3-(1H-pyrrol-1-yl)-(920650-00-6) Related Product Information
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