| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:(RS)-AMPA monohydrate
CAS:76463-67-7
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:(RS)-AMPA monohydrate
CAS:76463-67-7
Purity:95% Package:2mg;25mg;50mg
|
| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:(RS)-AMPA monohydrate
CAS:76463-67-7
Package:2mg/RMB 2400;25mg/RMB 9230;50mg/RMB 11996
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| | 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, hydrate (1:1) Basic information |
| | 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, hydrate (1:1) Chemical Properties |
| storage temp. | Store at -20°C, protect from light, stored under nitrogen | | form | Solid | | color | White to off-white | | Water Solubility | Water : 5 mg/mL (24.49 mM; ultrasonic and warming and heat to 60°C) |
| | 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, hydrate (1:1) Usage And Synthesis |
| Uses | (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors[1][2]. | | Biological Activity | (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
(RS)-AMPA monohydrate (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1]. | | References | [1]. Hsli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5. |
| | 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, hydrate (1:1) Preparation Products And Raw materials |
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