| Company Name: |
Wuhan Henruixintai Biological Co., Ltd.
|
| Tel: |
027-027-65522215 18163303831 |
| Email: |
360034463@qq.com |
| Products Intro: |
Product Name:tetrasodium 2-methyl-1,4-naphthylene bis(phosphate
CAS:131-13-5
Purity:97% Package:25g;100g
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:menadiol sodium diphosphate
CAS:131-13-5
|
| Company Name: |
CHEMSPEC API
|
| Tel: |
973-227-9330 |
| Email: |
info@chemspec-api.com |
| Products Intro: |
Product Name:MENADIOL SODIUM DIPHOSPHATE
CAS:131-13-5
|
|
| | tetrasodium 2-methyl-1,4-naphthylene bis(phosphate) Basic information |
| Product Name: | tetrasodium 2-methyl-1,4-naphthylene bis(phosphate) | | Synonyms: | tetrasodium 2-methyl-1,4-naphthylene bis(phosphate);MENADIOLSODIUMPHOSPHATE;MENADIOLSODIUMDIPHOSPHATE;1,4-Naphthalenediol, 2-methyl-, bis(dihydrogen phosphate), tetrasodium;1,4-Naphthalenediol, 2-methyl-, bis(dihydrogen phosphate), tetrasodium salt;1,4-Naphthalenediol, 2-methyl-, diphosphate, tetrasodium salt;1:4-Naphthaquinol-bisdisodium phosphate;2-Methyl-1,4-naphthaquinol bis(disodium phosphate) | | CAS: | 131-13-5 | | MF: | C11H8Na4O8P2 | | MW: | 422.083022 | | EINECS: | 205-012-1 | | Product Categories: | | | Mol File: | 131-13-5.mol |  |
| | tetrasodium 2-methyl-1,4-naphthylene bis(phosphate) Chemical Properties |
| Toxicity | LD50 subcutaneous in mouse: 350mg/kg |
| | tetrasodium 2-methyl-1,4-naphthylene bis(phosphate) Usage And Synthesis |
| Description | This may appear as pink to whitish crystals as the di-hydrate or
hexα-hydrate, either form is very soluble in water. This substance
was reported by the NAS survey of food additives, but no amounts
or technical effects (functionality) were reported. Similar substances have been used as dietary supplements in animal feeds for
those animals which may have been confronted with a Vitamin K
deficiency. | | Originator | Synkayvite,Roche,US,1941 | | Manufacturing Process | 2,000 g 2-methyl-1,4-naphthohydroquinone diphosphoryl chloride (from the quinone and POCl3) are dissolved in 2 liters ether and decomposed with 2 liters distilled water. The mixture is transferred to a separatory funnel and the aqueous layer separated from the ether layer, the latter being discarded. The aqueous layer is extracted with a further 2 liters of ether and again separated and discarded. The aqueous solution of the 2-methyl-1,4- naphthohydroquinone diphosphoric acid is extracted with successive portions of isobutyl carbinol in 500 cc quantities until the aqueous layer becomes almost colorless, after which this latter is discarded. The isobutyl carbinol solution is then concentrated to remove water and hydrochloric acid, and the crystalline residue neutralized with sodium hydroxide solution. The resulting solution of the sodium salt of 2-methyl-1,4-naphthohydroquinone diphosphoric ester is extracted with two successive portions of 1 liter acetone each and the
latter discarded. Methanol and acetone are then added, filtered, and the
product brought to crystallization by heating. Crystals of the sodium salt of 2-
methyl-1,4-naphthohydroquinone diphosphoric acid ester are sucked off. The
substance contains much moisture of crystallization and is dried in vacuum
until it contains 21-22% moisture of crystallization as determined by drying at
145°C at 2 mm vacuum. | | Therapeutic Function | Prothrombogenic vitamin | | Hazard | A poison. |
| | tetrasodium 2-methyl-1,4-naphthylene bis(phosphate) Preparation Products And Raw materials |
|