Angiotensin (1-7) (acetate)

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Angiotensin (1-7) (acetate) Basic information
Product Name:Angiotensin (1-7) (acetate)
Synonyms:Angiotensin (1-7) (acetate)
CAS:2855063-75-9
MF:C41H62N12O11.C2H4O2
MW:959.06
EINECS:
Product Categories:
Mol File:2855063-75-9.mol
Angiotensin (1-7) (acetate) Structure
Angiotensin (1-7) (acetate) Chemical Properties
form Solid
color White to off-white
SequenceAsp-Arg-Val-Tyr-Ile-His-Pro
Safety Information
MSDS Information
Angiotensin (1-7) (acetate) Usage And Synthesis
UsesAngiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium[1][2][3].
in vivo

Daily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment[3].

IC 50AT1 Receptor
References[1] Gómez-Mendoza DP, et al. Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486. DOI:10.1016/j.jprot.2019.103486
[2] Li P, et al. Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29(1 Pt 2):394-400. DOI:10.1161/01.hyp.29.1.394
[3] Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11(3):e0150861. DOI:10.1371/journal.pone.0150861
[4] Alzayadneh EM, et al. Angiotensin-(1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568(14)00314-3. DOI:10.1016/j.cellsig.2014.09.010
[5] Janatpour ZC, et al. Subcutaneous Administration of Angiotensin-(1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36(22):3115-3131. DOI:10.1089/neu.2019.6376
Angiotensin (1-7) (acetate) Preparation Products And Raw materials
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