| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
AUTAC1 manufacturers
- AUTAC1
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- $399.00
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2026-04-20
- CAS:2241669-09-8
- Purity: 99.45%
- Supply Ability: 10g
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| Product Name: | AUTAC1 | | Synonyms: | AUTAC1;6,9,12-Trioxa-2,16,19-triazaheneicosanoic acid, 18-[[[2-amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-17,20-dioxo-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3S)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, (18R)- | | CAS: | 2241669-09-8 | | MF: | C44H63FN8O11S | | MW: | 931.08 | | EINECS: | | | Product Categories: | | | Mol File: | 2241669-09-8.mol |  |
| | AUTAC1 Chemical Properties |
| density | 1.408±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 12.344±0.46(predicted) | | color | White to off-white |
| | AUTAC1 Usage And Synthesis |
| Uses | AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1]. | | References | [1] Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. DOI:10.1016/j.molcel.2019.09.009 |
| | AUTAC1 Preparation Products And Raw materials |
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