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| | Ethyl 6-aminopicolinate Basic information |
| | Ethyl 6-aminopicolinate Chemical Properties |
| Melting point | 56-58℃ | | Boiling point | 330℃ | | density | 1.192 | | Fp | 153℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | soluble in Methanol | | pka | 1.87±0.10(Predicted) | | form | powder to crystal | | color | White to Yellow to Green | | λmax | 337nm(MeOH)(lit.) |
| | Ethyl 6-aminopicolinate Usage And Synthesis |
| Chemical Properties | White to Yellow to Green powder to crystal. | | Synthesis | 6-Amino-2-pyridinecarboxylic acid (6.0 g, 43.5 mmol) was dissolved in ethanol (150 mL) at 0 °C and sulfoxide chloride (12.0 g, 101 mmol) was added slowly. The reaction mixture was heated to reflux with continuous stirring for 12 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was subsequently concentrated under reduced pressure. The pH was adjusted to 9 with saturated aqueous sodium carbonate solution and concentrated again under reduced pressure. Dichloromethane (150 mL) was added to the residue, stirred vigorously for 30 minutes at room temperature and filtered. The filtrate was concentrated under reduced pressure to give ethyl 6-aminopyridine-2-carboxylate (5.5 g, 76% yield). | | References | [1] Patent: WO2010/3048, 2010, A1. Location in patent: Page/Page column 107
[2] Patent: WO2010/19606, 2010, A1. Location in patent: Page/Page column 81-82
[3] Patent: WO2010/37127, 2010, A1. Location in patent: Page/Page column 109
[4] Patent: WO2010/88574, 2010, A1. Location in patent: Page/Page column 127-128
[5] Patent: WO2010/101949, 2010, A1. Location in patent: Page/Page column 132; 133 |
| | Ethyl 6-aminopicolinate Preparation Products And Raw materials |
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