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O-Phospho-L-tyrosine

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O-Phospho-L-tyrosine Basic information
Product Name:O-Phospho-L-tyrosine
Synonyms:H-TYR(H2PO3)-OH;H-TYR(P)-OH;H-TYR(PO3H2)-OH;L-3-[4-HYDROXYPHENYL]ALANINE 4'-PHOSPHATE;L-TYROSINE O-PHOSPHATE;H-Tyr(PO3)-OH;H-L-Tyr(PO3H2)-OH;L-Phosphotyrosine, (S)-2-Amino-3-(4-phosphonooxy-phenyl)-propionic acid
CAS:21820-51-9
MF:C9H12NO6P
MW:261.17
EINECS:
Product Categories:Amino Acids;Biochemistry;Biological-modified Amino Acids;Amino Acids & Derivatives;Aromatics;Chiral Reagents;Phosphorylating and Phosphitylating Agents
Mol File:21820-51-9.mol
O-Phospho-L-tyrosine Structure
O-Phospho-L-tyrosine Chemical Properties
Melting point 226-227°C
Boiling point 521.7±60.0 °C(Predicted)
density 1.591±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Aqueous Acid (Slightly), Water (Slightly, Sonicated)
form Solid
pka1.24±0.30(Predicted)
color White to Off-White
Optical Rotation-9.6° (C=0.01 g/ml, 1N HCL)
BRN 3150815
InChI1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
InChIKeyDCWXELXMIBXGTH-QMMMGPOBSA-N
SMILESN[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(O)=O
CAS DataBase Reference21820-51-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 21/22
Safety Statements 36/37
WGK Germany 3
F 10-21
HS Code 29225090
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
O-Phospho-L-tyrosine Usage And Synthesis
Chemical PropertiesWhite Solid
UsesO-Phospho-L-tyrosine is used in the study of tyrosine-phosphorylation, which has been linked to the malignant transformation of cells by various RNA tumor viruses. Plays a role in signal transduction.
DefinitionChEBI: A non-proteinogenic L-alpha-amino acid that is L-tyrosine phosphorylated at the phenolic hydroxy group.
Biological ActivityPhosphotyrosine acts as a docking site in protein regulation by stimulating interaction between tyrosine-phosphorylated proteins and phosphotyrosine domains of other proteins.
Purification MethodsPurify it by recrystallisation from H2O or H2O/EtOH. [Levene & Schormüller J Biol Chem 100 583 1933, Posternak & Graff Helv Chim Acta 28 1258 1945, Beilstein 14 III 1510.]
O-Phospho-L-tyrosine Preparation Products And Raw materials
Tag:O-Phospho-L-tyrosine(21820-51-9) Related Product Information
H-Tyr(Me)-OMe.HCl 3,5-Dichloro-L-tyrosine O-Benzyl-L-tyrosine benzyl ester hydrochloride O-Benzyl-L-tyrosine methyl ester hydrochloride 3-Nitro-L-tyrosine ethyl ester hydrochloride H-Tyr(Bzl)-OH O-Acetyl-L-tyrosine Phosphoric acid FITC-phosphotyramine Fmoc-O-Phospho-L-tyrosine O-Phospho-L-tyrosine Fmoc-Tyr(po(OBzl)OH)-OH Fmoc-Tyr(PO3(mdpse)2)-OH Tyrosine Boc-Tyr(PO3Me2)-OH H-Asn-Pro-Glu-Tyr(PO3H2)-OH Fmoc-Tyr(PO3Me2)-OH Fmoc-Tyr(PO3Bzl2)-OH