| | Fludiazepam Basic information |
| Product Name: | Fludiazepam | | Synonyms: | FLUDIAZEPAM;1,3-dihydro-7-chloro-5-(o-fluorophenyl)-1-methyl-2h-4-benzodiazepin-2-one;7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one;7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-chloro-5-(2-fluorophenyl)-1-methyl-1h-1,4-benzodiazepin-2(3h)-one;7-Chloro-5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one;7-CHLORO-(2-FLUOROPHENYL)-1,3-DIHYDRO-1-MENTHYL-2H-1,4-BENZODIAZEPIN-2-ONE;7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one | | CAS: | 3900-31-0 | | MF: | C16H12ClFN2O | | MW: | 302.73 | | EINECS: | | | Product Categories: | | | Mol File: | 3900-31-0.mol |  |
| | Fludiazepam Chemical Properties |
| Melting point | 88-92°; mp 69-72° (Sternbach) | | Boiling point | 498.1±45.0 °C(Predicted) | | density | 1.3159 (estimate) | | solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml | | pka | pKa 2.29±0.009(H2O) (Uncertain) | | form | A crystalline solid | | NIST Chemistry Reference | Fludiazepam(3900-31-0) |
| Toxicity | LD50 in mice (mg/kg): 910 orally; 360 i.p.; 1150 s.c. (Asami) |
| | Fludiazepam Usage And Synthesis |
| Description | Fludiazepam (Item No. 22424) is an analytical reference standard categorized as a benzodiazepine. Fludiazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications. | | Originator | Erispan,Sumitomo,Japan,1981 | | Uses | Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. | | Definition | ChEBI: Fludiazepam is a 1,4-benzodiazepinone, an organochlorine compound and an organofluorine compound. It has a role as an anxiolytic drug. It is functionally related to a monofluorobenzene and a diazepam. | | Manufacturing Process | A solution of 60 g of chromic anhydride in 40ml of water was added dropwise
to a suspension of 60 g of 2-aminomethyl-1-methyl-5-chloro-3-(ofluorophenyl)-
indole hydrochloride in 600 ml of acetic acid. The mixture was
stirred at room temperature overnight. To the reaction mixture was added 1.1
liters of ether and 1 liter of water and then 800 ml of 28% ammonium
hydroxide, in small portions. The ethereal layer separated, washed with water,
dried, and concentrated under reduced pressure. The residue (51.8 g) was
dissolved in 100 ml of ethanol, and 100 ml of 20% ethanolic hydrogen
chloride was added to the solution and the mixture was cooled. The
precipitate was collected by filtration to yield 46.5 g of 1-methyl-7-chloro-5-
(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one hydrochloride,
melting point 218°C (decomposed). Recrystallization from ethanol raised the
melting point to 218.5°C to 219°C (decomposed). | | Therapeutic Function | Anxiolytic | | References | [1] XIAO-PEN LEE . Rapid and highly sensitive analysis of benzodiazepines and tandospirone in human plasma by automated on-line column-switching UFLC-MS/MS[J]. Legal Medicine, 2017, 24: Pages 36-55. DOI: 10.1016/j.legalmed.2016.11.005 |
| | Fludiazepam Preparation Products And Raw materials |
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