| Company Name: |
JW & Y Pharmlab Co., Ltd.
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| Tel: |
021-64340559 13651849907; |
| Email: |
xinyu_shi@jwypharmlab.com.cn |
| Products Intro: |
Product Name:N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide
CAS:2695505-82-7
Purity:96% Package:mg;g;kg等可分装
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:RAF-IN-1
CAS:2695505-82-7
Package:100mg/RMB 17500;50mg/RMB 13800;25mg/RMB 10600
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N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide manufacturers
- RAF-IN-1
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- $2500.00 / 100mg
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2025-04-30
- CAS:2695505-82-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Basic information |
| Product Name: | N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide | | Synonyms: | N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide;RAF-IN-1;4-Pyridinecarboxamide, N-[4-methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)- | | CAS: | 2695505-82-7 | | MF: | C26H22F3N3O4 | | MW: | 497.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2695505-82-7.mol | ![N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Structure](CAS/20211123/GIF/2695505-82-7.gif) |
| | N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Chemical Properties |
| Boiling point | 644.7±55.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | pka | 11.02±0.70(Predicted) |
| | N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Usage And Synthesis |
| Uses | RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1]. | | IC 50 | BRafV600E: 29.4 nM (IC50); BRAFWT: 36 nM (IC50); c-Raf: 3.8 nM (IC50) | | References | [1] Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040. DOI:10.1016/j.ejmech.2021.114040 |
| | N-[4-Methyl-3-(2',3',5',6'-tetrahydro-4-oxospiro[2H-1,3-benzoxazine-2,4'-[4H]pyran]-7(3H)-yl)phenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide Preparation Products And Raw materials |
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