(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

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(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide Basic information
Product Name:(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide
Synonyms:JPS036;(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide;JPS036 New
CAS:2669785-85-5
MF:C51H66FN7O7S
MW:940.18
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Mol File:2669785-85-5.mol
(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide Structure
(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide Chemical Properties
Boiling point 1064.9±65.0 °C(Predicted)
density 1.29±0.1 g/cm3(Predicted)
pka13.25±0.70(Predicted)
Safety Information
MSDS Information
(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide Usage And Synthesis
UsesJPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
References[1] Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659. DOI:10.1021/acs.jmedchem.1c02179
(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide Preparation Products And Raw materials
Tag:(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide(2669785-85-5) Related Product Information
dTAGV-1 ARV-766 AU-15330 Tucidinostat (Chidamide) 4-Phenylbutyric acid Entinostat