| Company Name: |
R&D Systems, Inc
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| Tel: |
18003437475 18003437475 |
| Email: |
rdname@qq.com |
| Products Intro: |
Product Name:JPS036 New
CAS:2669785-85-5
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | JPS036;(2S,4R)-N-[(2-{[11-({4-[(2-aminophenyl)carbamoyl]phenyl}carbamoyl)undecyl]oxy}-4-(4-methyl-1,3-thiazol-5-yl)phenyl)methyl]-1-[(2S)-2-[(1-fluorocyclopropyl)formamido]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide;JPS036 New | | CAS: | 2669785-85-5 | | MF: | C51H66FN7O7S | | MW: | 940.19 | | EINECS: | | | Product Categories: | | | Mol File: | 2669785-85-5.mol |  |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| Boiling point | 1064.9±65.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | pka | 13.25±0.70(Predicted) |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Uses | JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1]. | | References | [1] Smalley JP, et al. Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells. J Med Chem. 2022;65(7):5642-5659. DOI:10.1021/acs.jmedchem.1c02179 |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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