| Company Name: |
Shanghai Boyle Chemical Co., Ltd.
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| Tel: |
021-50182298 021-50180596 |
| Email: |
sales@boylechem.com |
| Products Intro: |
Product Name:4'-Hydroxy TaMoxifen
CAS:82413-23-8
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:4'-Hydroxy TaMoxifen (contains up to 10% E isoMer)
CAS:82413-23-8
Package:2.5Mg,25Mg
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| | 4Hydroxy Tamoxifen Basic information |
| | 4Hydroxy Tamoxifen Chemical Properties |
| Melting point | 150-153°C | | Boiling point | 514.4±50.0 °C(Predicted) | | density | 1.092±0.06 g/cm3(Predicted) | | storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (Slightly), Dichloromethane, Methanol (Slightly) | | form | Solid | | pka | 10.32±0.15(Predicted) | | color | White to Off-White | | Stability: | Light Sensitive |
| | 4Hydroxy Tamoxifen Usage And Synthesis |
| Description | 4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines. | | Chemical Properties | White Solid | | Uses | A metabolite of Tamoxifen (T006000). | | References | [1] ROLAND LSER . In vivo and in vitro antiestrogenic action of 3-hydroxytamoxifen, tamoxifen and 4-hydroxytamoxifen[J]. European Journal of Cancer and Clinical Oncology, 1985, 21 8: Pages 985-990. DOI: 10.1016/0277-5379(85)90119-1
[2] H KIM CREWE. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4’-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.[J]. Drug Metabolism and Disposition, 2002, 32 1: 869-874. DOI: 10.1124/dmd.30.8.869
[3] H SEEGER. Inhibition of human breast cancer cell proliferation with estradiol metabolites is as effective as with tamoxifen.[J]. Hormone and Metabolic Research, 2004, 36 5: 277-280. DOI: 10.1055/s-2004-814480
[4] MARIA E CUEVAS Tracey E L. In vitro cytotoxicity of 4’-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B.[J]. Oncology reports, 2015, 33 1: 464-470. DOI: 10.3892/or.2014.3565
[5] GIORGIA URBINATI. Therapeutic potential of new 4-hydroxy-tamoxifen-loaded pH-gradient liposomes in a multiple myeloma experimental model.[J]. Pharmaceutical Research, 2010, 27 2: 327-339. DOI: 10.1007/s11095-009-0023-z |
| | 4Hydroxy Tamoxifen Preparation Products And Raw materials |
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