| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diamine
CAS:10023-54-8
Package:500mg
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| Company Name: |
Clearsynth Labs Limited
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| Tel: |
+91-22-26355700 |
| Email: |
info@clearsynth.com |
| Products Intro: |
Product Name:N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diaMine
CAS:10023-54-8
Remarks:CS-M-06163
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Aminoquinol
CAS:10023-54-8
Purity:98% HPLC LCMS Package:500mg/;1g/
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| Company Name: |
Wuhan Topule
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| Tel: |
+86-02787215551 +86-19945035818 |
| Email: |
2936752263@qq.com |
| Products Intro: |
Product Name:Aminoquinol
CAS:10023-54-8
Purity:98% hplc lcms Package:5MG;10MG;50MG;100MG,1G,5G， 5KG;1KG
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| | Aminoquinol Basic information |
| Product Name: | Aminoquinol | | Synonyms: | N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine tris(phosphate);Aminoquinol;7-Chloro-2-(o-chlorostyryl)-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diami;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-dia;1,4-Pentanediamine, N4-[7-chloro-2-[2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-;Aminoquinol
DISCONTINUED. Please see C609759.;GFRα/RET Signaling Activator, XIB-4035 | | CAS: | 10023-54-8 | | MF: | C26H31Cl2N3 | | MW: | 456.45 | | EINECS: | | | Product Categories: | | | Mol File: | 10023-54-8.mol |  |
| | Aminoquinol Chemical Properties |
| Melting point | 223-225° | | Boiling point | 597.1±50.0 °C(Predicted) | | density | 1.191±0.06 g/cm3(Predicted) | | storage temp. | RT | | solubility | Soluble in DMSO (up to 25 mg/ml with warming). | | pka | 10.47±0.25(Predicted) | | form | solid | | color | Light brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | InChIKey | CMLVHSVFSYNMGM-WYMLVPIESA-N |
| WGK Germany | WGK 3 | | HazardClass | IRRITANT | | Storage Class | 6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Aquatic Chronic 4 |
| | Aminoquinol Usage And Synthesis |
| Description | XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50?= 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells.1?Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3? GDNF agonists may be a new class of Parkinson’s disease therapeutics.4 | | References | [1] KIMIKO TOKUGAWA . XIB4035, a novel nonpeptidyl small molecule agonist for GFRα-1[J]. Neurochemistry international, 2003, 42 1: Pages 81-86. DOI:10.1016/s0197-0186(02)00053-0
[2] KRISTIAN L HEDSTROM. Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014: 2325-2330. DOI:10.1073/pnas.1308889111
[3] YU-LIN HSIEH . Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy[J]. Experimental Neurology, 2018, 300: Pages 87-99. DOI:10.1016/j.expneurol.2017.10.026
[4] ANJA DRINKUT. Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model[J]. Cell Death & Disease, 2016, 7 9: e2359-e2359. DOI:10.1038/cddis.2016.263 |
| | Aminoquinol Preparation Products And Raw materials |
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