2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-

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2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- manufacturers
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Basic information
Product Name:2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-
Synonyms:2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-;POLA1 inhibitor 1
CAS:2217671-41-3
MF:C26H27NO4
MW:417.5
EINECS:
Product Categories:
Mol File:2217671-41-3.mol
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Structure
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Chemical Properties
Boiling point 643.1±55.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
pka-95.65±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Usage And Synthesis
UsesPOLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
in vivo

POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1].

References[1] Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253. DOI:10.1016/j.bioorg.2020.104253
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- Preparation Products And Raw materials
Tag:2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-(2217671-41-3) Related Product Information
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