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| | PROCATEROL HYDROCHLORIDE Basic information |
| Product Name: | PROCATEROL HYDROCHLORIDE | | Synonyms: | Procaterol hydrochlorid;erythro-8-hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1h)-quinolinone;2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, rel- (9CI);Procaterol HCl,Procaterol hydrochloride;8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one hydrate hydrochloride;2(1H)-Quinolinone, 8-hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, (R*,S*)-;2(1H)-Quinolinone, 8-hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, (R*,S*)-(+-)-;PROCATEROL HCL | | CAS: | 62929-91-3 | | MF: | C16H23ClN2O3 | | MW: | 326.82 | | EINECS: | 263-763-0 | | Product Categories: | Adrenoceptor | | Mol File: | 62929-91-3.mol |  |
| | PROCATEROL HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble to 100 mM in water and to 100 mM in DMSO | | form | Powder | | color | White to off-white | | Stability: | Hygroscopic | | InChI | 1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1 | | InChIKey | AEQDBKHAAWUCMT-CVHDTDHSSA-N | | SMILES | Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12 |
| WGK Germany | 2 | | RTECS | VC8296000 | | Storage Class | 11 - Combustible Solids |
| | PROCATEROL HYDROCHLORIDE Usage And Synthesis |
| Description | Procaterol is an agonist of β2-adrenergic receptors (β2-ARs). It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (; IC50s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine in isolated guinea pig trachea (EC50 = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml. | | Uses | adrenergic agonists | | Uses | Procaterol Hydrochloride is a short-acting pulmonary β2-agonist for asthma treatment. | | General Description | Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells. | | Biological Activity | Specific and very potent β 2 agonist. | | Biochem/physiol Actions | β2-adrenoceptor agonist; bronchodilator. | | storage | Store at RT | | References | [1] S MARULLO. Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.[J]. EMBO Journal, 1990, 9 5: 1471-1476. DOI: 10.1002/j.1460-2075.1990.tb08264.x
[2] HIDEO KIKKAWA Katsuo I Kazuaki Naito. Tracheal Relaxing Effects and β2-Selectivity of TA-2005, a Newly Developed Bronchodilating Agent, in Isolated Guinea Pig Tissues[J]. Japanese journal of pharmacology, 1991, 57 2: Pages 175-185. DOI: 10.1254/jjp.57.175
[3] SHIRO YOSHIZAKI. Sympathomimetic amines having a carbostyril nucleus[J]. Journal of Medicinal Chemistry, 1976, 19 9: 1138-1142. DOI: 10.1021/jm00231a011
[4] MIRZA. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation[J]. Clinical and Experimental Allergy, 2008, 28 5: 644-652. DOI: 10.1046/j.1365-2222.1998.00263.x |
| | PROCATEROL HYDROCHLORIDE Preparation Products And Raw materials |
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