2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-

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2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Basic information
Product Name:2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-
Synonyms:2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-;5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine;TAE648
CAS:2769753-10-6
MF:C23H27ClN6O2S
MW:487.02
EINECS:
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Mol File:2769753-10-6.mol
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Structure
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Chemical Properties
Boiling point 717.9±70.0 °C(Predicted)
density 1.340±0.06 g/cm3(Predicted)
pka8.98±0.10(Predicted)
Safety Information
MSDS Information
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Usage And Synthesis
UsesTAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341)[1].
References[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. DOI:10.1016/j.cell.2020.10.038
[2] Cha HJ, et al. Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells. Int J Oncol. 2017 Apr;50(4):1279-1288. DOI:10.3892/ijo.2017.3913
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- Preparation Products And Raw materials
Tag:2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]-(2769753-10-6) Related Product Information
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