| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
| Email: |
han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:VH032-NH-Boc
CAS:2010986-19-1
Purity:95% Package:250MG;1G Remarks:211439
|
| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-89903022 18679456698 |
| Email: |
zilong@hizyme.com |
| Products Intro: |
Product Name:VH032-NH-CO-CH2-NHBoc
CAS:2010986-19-1
Purity:98% Package:100mg；200mg
|
| Company Name: |
Xi'an Qiyue Biotechnology Co., Ltd.
|
| Tel: |
400-400-6966-012-012 17778955912 |
| Email: |
2957605606@qq.com |
| Products Intro: |
Product Name:VH032-NH-CO-CH2-NHBoc
CAS:2010986-19-1
Purity:99.99% Package:10mg;50mg
|
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| | L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information |
| | L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties |
| Boiling point | 856.3±65.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | pka | 11.26±0.46(Predicted) |
| | L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis |
| Uses | VH032-NH-CO-CH2-NHBoc is a Boc-modified VH032 (HY-120217) that acts as a ligand for VHL to recruit von Hippel-Lindau (VHL) proteins. VH032-NH-CO-CH2-NHBoc will remove the Boc protection under acidic conditions, and connect with the target protein ligand through a linker to form a PROTAC molecule, which is a key intermediate for the synthesis of PROTAC based on VHL ligand. | | IC 50 | VHL |
| | L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]glycyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials |
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