Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)-

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Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)- Basic information
Product Name:Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)-
Synonyms:Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)-;1-(2,6-difluorophenylsulfonyl)-4-(naphthalen-2-ylsulfonyl)piperazine;PKM2 activator 2;PKM2 activator 2, 10 mM in DMSO
CAS:1186660-06-9
MF:C20H18F2N2O4S2
MW:452.49
EINECS:
Product Categories:
Mol File:1186660-06-9.mol
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)- Structure
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)- Chemical Properties
Boiling point 624.7±65.0 °C(Predicted)
density 1.480±0.06 g/cm3(Predicted)
pka-7.86±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)- Usage And Synthesis
UsesPKM2 activator 2 (compound 28) is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 can restore normal glycolytic metabolism in cells[1].
DefinitionChEBI: 1-(2,6-difluorophenyl)sulfonyl-4-(2-naphthalenylsulfonyl)piperazine is a sulfonic acid derivative and a member of naphthalenes.
IC 50PKM2: 66 nM (EC50)
References[1] Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53(3):1048-55. DOI:10.1021/jm901577g
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)- Preparation Products And Raw materials
Tag:Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-(2-naphthalenylsulfonyl)-(1186660-06-9) Related Product Information
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-, hydrochloride (1:1) Benzenesulfonamide, 4-fluoro-N-[2-[4-[(4-fluorophenyl)sulfonyl]-1-piperazinyl]ethyl]- 1-((5-Bromo-2-fluorophenyl)sulfonyl)-4-methylpiperazine N-(2-aminoethyl)-4-fluoro-N-methylbenzene-1-sulfonamide hydrochloride 1-(2,6-Difluorobenzenesulfonyl)piperazine (4-Fluoro-3-((4-methylpiperazin-1-yl)sulfonyl)phenyl)boronic acid