2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)-

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2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- manufacturers
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- Basic information
Product Name:2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)-
Synonyms:Anti-inflammatory agent 17;2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)-
CAS:2763226-84-0
MF:C20H23NO5
MW:357.4
EINECS:
Product Categories:
Mol File:2763226-84-0.mol
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- Structure
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- Chemical Properties
Boiling point 599.0±50.0 °C(Predicted)
density 1.265±0.06 g/cm3(Predicted)
pka7.80±0.45(Predicted)
Safety Information
MSDS Information
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- Usage And Synthesis
UsesAnti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1].
in vivo

Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice[1].

Animal Model:C57/BL6 mice[1]
Dosage:20 mg/kg
Administration:Intragastric administration
Result:Exhibited protective effect on LPS-induced ALI in mice.
IC 50TNF-α: 2.576 μM (IC50); IL-6: 8.254 μM (IC50)
References[1] Wang X,et al. Design, synthesis and bioactivity evaluation of fisetin derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury. Bioorg Med Chem. 2021; 49:116456. DOI:10.1016/j.bmc.2021.116456
2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)- Preparation Products And Raw materials
Tag:2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[5-[3-(dimethylamino)propoxy]-2-hydroxyphenyl]-, (2E)-(2763226-84-0) Related Product Information
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