2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]-

2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- manufacturers

2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- Basic information

Product Name:	2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]-
Synonyms:	2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]-;EGFR-IN-40
CAS:	1466445-39-5
MF:	C23H20N6O3
MW:	428.44
EINECS:
Product Categories:
Mol File:	1466445-39-5.mol

2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- Chemical Properties

density	1.33±0.1 g/cm3(Predicted)
pka	13.02±0.70(Predicted)

Safety Information

MSDS Information

2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- Usage And Synthesis

Uses	EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].
IC 50	BTK: 1.2 nM (IC₅₀); EGFR: 5.3 nM (IC₅₀); ITK: 46.1 nM (IC₅₀)
References	[1] Dou Dou, et al. Discovery of Pteridine-7(8 H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2022 Feb 10;65(3):2694-2709. DOI:10.1021/acs.jmedchem.1c02208

2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]- Preparation Products And Raw materials

Tag:2-Propenamide, N-[3-[2-[(4-methoxyphenyl)amino]-6-methyl-7-oxo-8(7H)-pteridinyl]phenyl]-(1466445-39-5) Related Product Information

EGFR Protein, HUMAN (621A.A, HEK293, FC) EGFR protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) HER2/CD340 protein, HUMAN (BIOTINYLATED, HEK293, HIS) HER3 Protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) AZD-9291 Zanidatamab