| Company Name: |
Chengdu Youngshe Chemical Co., Ltd.
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| Tel: |
+86-17380623303 +86-17380623303 |
| Email: |
Caroline@youngshechem.com |
| Products Intro: |
Product Name:PAMP-12
CAS:929905-12-4
Purity:95% Package:1G; 10G; 100G
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
Eric@peptidego.com |
| Products Intro: |
Product Name:FRKKWNKWALSR
CAS:929905-12-4
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Shaoxing Junyu Biotechnology Co., LTD
|
| Tel: |
0571-88211921 19105816207 |
| Email: |
sales4@gotopbio.com |
| Products Intro: |
Product Name:PAMP-12
CAS:929905-12-4
Purity:99% HPLC MS Package:1mg；5mg；10mg；100mg；500mg；1kg；5kg；25kg
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| Company Name: |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
|
| Tel: |
0571-87213919 17306812703 |
| Email: |
3007955328@qq.com |
| Products Intro: |
Product Name:FRKKWNKWALSR
CAS:929905-12-4
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| | L-Arginine, L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl- Basic information |
| | L-Arginine, L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl- Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | form | Solid | | pka | 3.23±0.10(Predicted) | | color | White to off-white |
| | L-Arginine, L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl- Usage And Synthesis |
| Uses | PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells[1]. | | References | [1] Kamohara M, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 2005;330(4):1146-1152. DOI:10.1016/j.bbrc.2005.03.088
[2] Chen E, et al. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target. Gastroenterology. 2021;160(5):1709-1724. DOI:10.1053/j.gastro.2020.12.076 |
| | L-Arginine, L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl- Preparation Products And Raw materials |
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