NISTC4136269

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Company Name: Chengdu Kamel Pharmaceutical Co., Ltd  
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NISTC4136269 Basic information
Product Name:NISTC4136269
Synonyms:NISTC4136269;5,6-DiMethoxy-3,3-diMethyl-2,3-dihydro-1H-inden-1-one;2,3-dihydro-5,6-diMethoxy-3,3-diMethyl-1H-inden-1-one;5,6-dimethoxy-3,3-dimethyl-2H-inden-1-one;1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-3,3-dimethyl-
CAS:4136-26-9
MF:C13H16O3
MW:220.26
EINECS:
Product Categories:
Mol File:4136-26-9.mol
NISTC4136269 Structure
NISTC4136269 Chemical Properties
Melting point 68.5-69 °C
Boiling point 351.2±42.0 °C(Predicted)
density 1.093±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
AppearanceLight yellow to brown Solid
Safety Information
MSDS Information
NISTC4136269 Usage And Synthesis
Synthesis
5,6-Dimethoxy-1,1-dimethyl-2,3-dihydro-1H-indene

51458-29-8

NISTC4136269

4136-26-9

The general procedure for the synthesis of 5,6-dimethoxy-3,3-dimethyl-2,3-dihydro-1H-inden-1-one from the compound (CAS: 51458-29-8) is as follows: to a solution of 2.6 g (about 13 mmol) of the compound in benzene (96 mL) was added 13.7 g (64 mmol) of pyridinium chlorochromate and 31.8 g of diatomaceous earth, and the mixture was stirred at 85 °C for 1 hour. Upon completion of the reaction, the insoluble material was removed by diatomaceous earth filtration and the residue on the diatomaceous earth was washed with ether and ethyl acetate. The filtrate and washings were combined and subsequently concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography to give 2.1 g (yield: 77%) of the target product 5,6-dimethoxy-3,3-dimethylindan-1-one as a colorless oil.

References[1] Patent: US6340682, 2002, B1. Location in patent: Page column 43-44
NISTC4136269 Preparation Products And Raw materials
Raw materials5,6-Dimethoxy-1,1-dimethyl-2,3-dihydro-1H-indene-->Celite-->Pyridinium chlorochromate-->Benzene
Tag:NISTC4136269(4136-26-9) Related Product Information
3-Methyl-5,6-dimethoxy-2,3-dihydro-1H-indene-1-one 6-Methoxy-3,3-dimethylindan-1-one 5-methoxy-3,3-dimethyl-1-indanone 1H-Inden-1-one,3-ethyl-2,3-dihydro-5,6-dimethoxy-,(3R)-(9CI) 1H-Inden-1-one, 2,3-dihydro-4-methoxy-3,3-dimethyl- 5,7-DiMethoxy-3,3-diMethyl-2,3-dihydro-1H-inden-1-one