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| | 4-[(3S)-1-(4-hydroxyphenyl)penta-1,4-dien-3-yl]phenol Basic information |
| | 4-[(3S)-1-(4-hydroxyphenyl)penta-1,4-dien-3-yl]phenol Chemical Properties |
| Melting point | 69-71 °C(Solv: chloroform (67-66-3)) | | Boiling point | 429.4±40.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 9.88±0.26(Predicted) | | form | Powder | | color | Yellow to orange | | LogP | 3.710 (est) |
| | 4-[(3S)-1-(4-hydroxyphenyl)penta-1,4-dien-3-yl]phenol Usage And Synthesis |
| Description | Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) possess appreciable estrogen receptor binding activity, they can stimulate the proliferation of estrogen-
dependent T47D breast cancer cells, and their stimulatory effects could be blocked by an estrogen antagonist, indicating that they are estrogen agonists.
trans- and cis-Hinokiresinols have similar free radical scavenging and anti-inflammatory activities, they also have anti-ischemic effects, only trans-hinokiresinol can significantly decrease neuronal injury in cultured cortical neurons exposed to oxygen-glucose deprivation followed by re-oxygenation.
3. Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils.
4. Hinokiresinol has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. | | Uses | (-)-Hinokiresinol (Hinokiresinol; trans-Hinokiresinol) can be isolated from Chamaecyparis obtusa. (-)-Hinokiresinol has weak termiticidal activity but strong antifeedant and repellent activity[1]. | | Definition | ChEBI: (-)-hinokiresinol is a 1,3-bis(p-hydroxyphenyl)pentane-1,4-diene that has 1E,3S configuration. A natural product found in Chamaecyparis obtusa. It has a role as a metabolite. It is a norlignan and a 1,3-bis(p-hydroxyphenyl)pentane-1,4-diene. | | target | Estrogen receptor | NOS | IL Receptor | TNF-α | Progestogen receptor | | References | [1] Morikawa T, et al. Antitermitic activity of extracts from Chamaecyparis obtusa branch heartwood[J]. European Journal of Wood and Wood Products, 2014, 72: 651-657. |
| | 4-[(3S)-1-(4-hydroxyphenyl)penta-1,4-dien-3-yl]phenol Preparation Products And Raw materials |
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