2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)-

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2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)- manufacturers
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)- Basic information
Product Name:2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)-
Synonyms:2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)-;Microtubule inhibitor 5
CAS:2416338-55-9
MF:C22H15FN2O4
MW:390.36
EINECS:
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Mol File:2416338-55-9.mol
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)- Structure
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)- Chemical Properties
Boiling point 695.8±55.0 °C(Predicted)
density 1.371±0.06 g/cm3(Predicted)
pka11.38±0.20(Predicted)
Safety Information
MSDS Information
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)- Usage And Synthesis
UsesMicrotubule inhibitor 5 (compound 17f) is a potent microtubule inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC50 value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability[1].
References[1] Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435. DOI:10.1016/j.bmc.2020.115435
2,5-Piperazinedione, 3-[[3-(4-fluorophenoxy)phenyl]methylene]-6-(2-furanylmethylene)-, (3Z,6Z)- Preparation Products And Raw materials
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