2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro-

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2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro- Basic information
Product Name:2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro-
Synonyms:2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro-;BTK-IN-10
CAS:2758596-07-3
MF:C25H24F2N4O2
MW:450.48
EINECS:
Product Categories:
Mol File:2758596-07-3.mol
2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro- Structure
2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro- Chemical Properties
density 1.39±0.1 g/cm3(Predicted)
pka14.48±0.10(Predicted)
Safety Information
MSDS Information
2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro- Usage And Synthesis
UsesBTK-IN-10 is a potent BTK inhibitor with IC50s of <5 nM for wild-type BTK or mutated BTK (C481S), respectively (WO2022012509A1; example 111)[1].
References[1] Chunchao Yue, et al. Compound as brain-permeable btk or her2 inhibitor, preparation method therefor, and use thereof. WO2022012509A1.
2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro- Preparation Products And Raw materials
Tag:2H-Pyran-2-methanol, 5-[8-amino-1-[4-(difluorophenylmethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]tetrahydro-(2758596-07-3) Related Product Information
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