1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]-

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1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- manufacturers

  • Dot1L-IN-7
  • Dot1L-IN-7 pictures
  • $1520.00
  • 2026-04-20
  • CAS:2580940-76-5
  • Purity:
  • Supply Ability: 10g
1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- Basic information
Product Name:1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]-
Synonyms:1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]-;Dot1L-IN-7
CAS:2580940-76-5
MF:C23H27N9O2
MW:461.52
EINECS:
Product Categories:
Mol File:2580940-76-5.mol
1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- Structure
1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- Chemical Properties
density 1.38±0.1 g/cm3(Predicted)
pka11.16±0.70(Predicted)
Safety Information
MSDS Information
1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- Usage And Synthesis
UsesDot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].
IC 50DOT1L: 1 μM (IC50)
References[1] Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023. DOI:10.1016/j.ejmech.2019.112023
1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]- Preparation Products And Raw materials
Tag:1H-1,2,4-Triazole-1-acetamide, N-[2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)ethyl]-3-[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]-(2580940-76-5) Related Product Information
UNC 1999 EPZ015666 GSK-3326595 DS-3201 MRTX-1719 SGC0946