2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-

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2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Suppliers list
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
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2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- manufacturers
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Basic information
Product Name:2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-
Synonyms:2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-;JNK3 inhibitor-2
CAS:2366264-18-6
MF:C20H14N2O2
MW:314.34
EINECS:
Product Categories:
Mol File:2366264-18-6.mol
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Structure
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Chemical Properties
Boiling point 557.4±50.0 °C(Predicted)
density 1.334±0.06 g/cm3(Predicted)
pka15.06±0.20(Predicted)
Safety Information
MSDS Information
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Usage And Synthesis
UsesJNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 μM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].
IC 50JNK1: >100 μM (IC50); JNK2: >100 μM (IC50); JNK3: 0.25 μM (IC50)
References[1] Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445. DOI:10.1016/j.ejmech.2020.112445
2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)- Preparation Products And Raw materials
Tag:2(1H)-Quinoxalinone, 3,4-dihydro-3-[2-(1-naphthalenyl)-2-oxoethylidene]-, (3Z)-(2366264-18-6) Related Product Information
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