Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- manufacturers
- BCR-ABL-IN-5
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- $2500.00
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2026-07-27
- CAS:1795736-60-5
- Purity:
- Supply Ability: 10g
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| | Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- Basic information |
| | Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- Chemical Properties |
| Boiling point | 807.9±65.0 °C(Predicted) | | density | 1.455±0.06 g/cm3(Predicted) | | pka | 14.49±0.40(Predicted) |
| | Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- Usage And Synthesis |
| Uses | BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1]. | | References | [1] Ashraf K El-Damasy, et al. Design, synthesis, and biological evaluations of novel 3-amino-4-ethynyl indazole derivatives as Bcr-Abl kinase inhibitors with potent cellular antileukemic activity. Eur J Med Chem. 2020 Dec 1;207:112710. DOI:10.1016/j.ejmech.2020.112710 |
| | Methanone, [4-[4-(3-amino-1H-indazol-4-yl)benzoyl]-1-piperazinyl](2,4-dichlorophenyl)- Preparation Products And Raw materials |
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